**CervoMed Inc. Reports Fiscal Year 2025 Financial Results and Provides Business Update**
CervoMed Inc., a clinical-stage biotechnology company focused on developing treatments for age-related brain disorders, released its financial results for the fiscal year ended December 31, 2025, reporting a net loss of $27.0 million, compared to a net loss of $16.3 million for the previous fiscal year. The company's grant revenue, primarily from the National Institute on Aging (NIA) grant supporting the RewinD-LB Trial, decreased to $4.0 million from $9.7 million in the prior year, reflecting the completion of key trial phases. Research and development expenses increased to $21.8 million from $18.8 million, driven by personnel costs, outsourced consulting, and manufacturing improvements, partially offset by decreased clinical spending on the RewinD-LB Trial. General and administrative expenses also rose to $10.5 million from $9.2 million, mainly due to increased personnel costs and professional fees.
The company's cash, cash equivalents, and marketable securities totaled $20.9 million as of December 31, 2025. Net cash used in operating activities was $23.4 million, while net cash provided by financing activities was $4.6 million, primarily from the sale of common stock under an at-the-market offering. The company emphasized its ongoing need for additional capital to fund operations and advance its lead drug candidate, neflamapimod, through clinical development. The company anticipates seeking additional funding through equity offerings, debt financings, or strategic collaborations.
Operationally, CervoMed highlighted key milestones, including the ongoing Phase 2a clinical trials for neflamapimod in non-fluent variant primary progressive aphasia (nfvPPA) and Recovery After Stroke (RAS), with initial biomarker and topline clinical data expected in mid and late 2026, respectively. The company also announced neflamapimod's selection for inclusion in the EXPERTS-ALS platform in the UK, with the first patient dosing anticipated by the end of 2026. CervoMed is planning to initiate a Phase 3 trial in DLB in the second half of 2026, pending available funding.
CervoMed's strategy remains focused on advancing neflamapimod as a potential first-in-class treatment for DLB without Alzheimer's Disease (AD) co-pathology and exploring strategic collaborations to maximize its value. The company is also working on pre-Phase 3 manufacturing improvements to address stability issues identified during the RewinD-LB Trial. The company acknowledges that its ability to continue as a going concern is dependent on its ability to secure additional funding and execute its business strategies.
About CervoMed Inc.
CervoMed Inc. is a clinical-stage biotechnology company developing treatments for age-related neurological disorders. Its lead candidate, neflamapimod, is an oral small molecule targeting neuroinflammation and synaptic dysfunction in diseases like dementia with Lewy bodies (DLB), FTD, and stroke recovery. The company focuses on early intervention, leveraging its understanding of neurodegenerative mechanisms to slow or reverse disease progression.
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