Ultragenyx Pharmaceutical Inc. reported a total revenue of $166.5 million for the second quarter of 2025, marking a 13% increase from $147.0 million in the same period of 2024. The growth was driven by a rise in product sales, which reached $80.8 million, up from $73.8 million year-over-year. Royalty revenue also saw an increase, climbing to $85.7 million from $73.2 million. For the first half of 2025, total revenues amounted to $305.8 million, a 20% increase compared to $255.9 million in the first half of 2024. Despite this revenue growth, the company reported a net loss of $115.0 million for the quarter, slightly improved from a loss of $131.6 million in the prior year.
The financial performance reflects a strategic focus on expanding product offerings and market presence. Notably, the launch of Evkeeza in Japan and various European markets contributed significantly to revenue growth. However, sales of Crysvita, the company's flagship product, experienced a decline due to order timing issues in Latin America. The company’s total operating expenses for the quarter were $274.4 million, up from $263.4 million in the same quarter last year, primarily driven by increased research and development costs.
Ultragenyx has also made significant operational advancements, including the consolidation of Amlogenyx Inc., a subsidiary focused on gene therapy for neurodegenerative diseases. The company continues to develop its pipeline, which includes several gene therapy candidates and biologics. As of June 30, 2025, Ultragenyx had $539.0 million in cash, cash equivalents, and marketable securities, providing a solid financial foundation for ongoing and future projects.
Looking ahead, Ultragenyx anticipates continued investment in research and development, with expectations of annual losses persisting in the near term as the company advances its clinical programs and seeks regulatory approvals. The company may require additional capital to support its operations and product development, which could involve equity offerings or strategic collaborations. The management remains optimistic about the potential market opportunities for its products, particularly as it navigates the complexities of the biopharmaceutical landscape.
About Ultragenyx Pharmaceutical Inc.
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